Prevention of Cholera-induced Intestinal Secretion in the Cat by Aspirin

BENNETT 1 has suggested that cholera toxin stimulates the release or synthesis of prostaglandins (PG) which, in turn, interact with the cyclic 3′,5′-adenosine monophosphate system to produce diarrhoea. PGs might also be involved in the diarrhoea associated with medullary carcinoma of the thyroid, th...

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Bibliographic Details
Published in:Nature (London) 1972-08, Vol.238 (5362), p.273-274
Main Authors: FINCK, A. DONALD, KATZ, RONALD L
Format: Article
Language:English
Subjects:
Animals
Aspirin - administration & dosage
Aspirin - pharmacology
Aspirin - therapeutic use
Cats
Cholera - drug therapy
Cholera - metabolism
Diarrhea - prevention & control
Disease Models, Animal
Female
Humanities and Social Sciences
Intestinal Secretions - drug effects
letter
Male
multidisciplinary
Prostaglandins - biosynthesis
Science
Science (multidisciplinary)
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Summary:BENNETT 1 has suggested that cholera toxin stimulates the release or synthesis of prostaglandins (PG) which, in turn, interact with the cyclic 3′,5′-adenosine monophosphate system to produce diarrhoea. PGs might also be involved in the diarrhoea associated with medullary carcinoma of the thyroid, the carcinoid syndrome and ganglioneuroma 2–4 . Diarrhoea has also been observed in patients with phaeochromocytoma (unpublished results of R. L. K.) and large amounts of PGE 2 and PGF 2α have been reported in phaeochromocytoma 2 . Vane 5 , Smith and Willis 6 , and Ferreira et al. 7 showed that aspirin inhibits the synthesis of PGs in several in vitro systems. Bennett 1 therefore suggested that aspirin might prevent the diarrhoea associated with cholera. Our study was undertaken to investigate this possibility in cats.
ISSN:0028-0836
1476-4687
DOI:10.1038/238273a0