The Acute Effects of Elimination of the Moderator Reflexes Upon Cardiac Output and Total Peripheral Resistance in the Anesthetized Dog

The abrupt rise in mean arterial pressure resulting from elimination of the moderator reflexes is not accompanied by a significant increase in cardiac output. The acute hypertension is therefore attributed to a severe generalized vasoconstriction. The severity of this vasomotor response progressivel...

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Bibliographic Details
Published in:Circulation research 1955-07, Vol.3 (4), p.415-421
Main Authors: Levy, Matthew N, Brind, Shirley H, Brandlin, Frederick R
Format: Article
Language:English
Subjects:
Animals
Blood Vessels - physiology
Cardiac Output
Carotid Sinus - physiology
Dogs
Heart - physiology
Hypertension
Old Medline
Vascular Resistance
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Summary:The abrupt rise in mean arterial pressure resulting from elimination of the moderator reflexes is not accompanied by a significant increase in cardiac output. The acute hypertension is therefore attributed to a severe generalized vasoconstriction. The severity of this vasomotor response progressively diminishes during the interval immediately following denervation.
ISSN:0009-7330
1524-4571
DOI:10.1161/01.res.3.4.415