Simulation Device for Preliminary Tablet Compression Studies

• Published in: Journal of pharmaceutical sciences 1972-08, Vol.61 (8), p.1313-1315
• Main Authors: Rees, John E., Hersey, John A., Cole, Ewart T.
• Format: Article
• Language: English
• Subjects: Compression; Compression, tablets—preliminary testing, rotary tableting machine simulation device; Drug Compounding - instrumentation; rotary tableting machine simulation device; Rotary tableting machine-simulation device for preliminary tablet compression testing; simulation of double-acting compression cycle of a rotary tableting machine; Tablet compression-preliminary testing; Tablet compression—preliminary testing, simulation of double-acting compression cycle of a rotary tableting machine; Tablets - standards; tablets-preliminary testing
• ISSN: 0022-3549; 1520-6017
• DOI: 10.1002/jps.2600610832

A system was designed to simulate the double-acting compression effect of rotary tableting machines commonly used to prepare pharmaceutical compressed tablets. The device was constructed for use with a universal mechanical testing instrument, but the principle could also be applied to other types of compressing equipment including a modified reciprocating tablet machine. The double-acting compression is achieved by controlled downward movement of the die at a slower rate than the simultaneous downward movement of the upper punch. Adjustable components also allow control of: (a) the rate of loading, (b) the relative rate of movement of the die and upper punch, (c) the time at which movement of the die commences, (d) the depth of compression in the die, and (e) precompression of the powder bed. These controls permit simulation of a range of machine settings for different types of rotary tablet presses.