Effects of neurotensin in amygdaloid spatial learning mechanisms

Neurotensin (NT) acts as a neurotransmitter and/or neuromodulator and plays a role in learning and reward related processes. The central nucleus of amygdala (CeA) participates in the regulation of memory and learning mechanisms. In Morris water maze test, rats were microinjected with NT or neurotens...

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Bibliographic Details
Published in:Behavioural brain research 2010-07, Vol.210 (2), p.280-283
Main Authors: László, Kristóf, Tóth, Krisztián, Kertes, Erika, Péczely, László, Ollmann, Tamás, Lénárd, László
Format: Article
Language:English
Subjects:
Amygdala - drug effects
Amygdala - physiology
Animals
Avoidance Learning - drug effects
Behavior, Animal - drug effects
Behavioral psychophysiology
Biological and medical sciences
Central nucleus of amygdala
Drug Interactions
Fundamental and applied biological sciences. Psychology
Male
Memory
Morris water maze
Neurotensin
Neurotensin - pharmacology
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Pyrazoles - pharmacology
Quinolines - pharmacology
Rats
Rats, Wistar
Reaction Time - drug effects
Receptors, Neurotensin - antagonists & inhibitors
Space Perception - drug effects
Statistics, Nonparametric
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Summary:Neurotensin (NT) acts as a neurotransmitter and/or neuromodulator and plays a role in learning and reward related processes. The central nucleus of amygdala (CeA) participates in the regulation of memory and learning mechanisms. In Morris water maze test, rats were microinjected with NT or neurotensin receptor-1 (NTS1) antagonist SR 48692 (ANT). NT significantly reduced the escape latency. Effect of NT was blocked by ANT pretreatment. Our results show that in the rat CeA NT facilitates spatial learning. We clarified that NTS1s are involved in this action.
ISSN:0166-4328
1872-7549
DOI:10.1016/j.bbr.2010.02.038