Relationship between oligomer and functional serum mannose-binding lectin in chronic renal failure

Eur J Clin Invest 2010; 40 (10): 865–873 Introduction  Mannose‐binding lectin (MBL) plays an important role in first‐line host defence against pathogens via the lectin pathway. The binding affinity for ligands is greatly increased by oligomerization, although the basic triplet does not bind solid ph...

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Published in:European journal of clinical investigation 2010-10, Vol.40 (10), p.865-873
Main Authors: Satomura, Atsushi, Fujita, Takayuki, Fuke, Yoshinobu, Yanai, Mitsuru, Kumasaka, Kazunari, Takayama, Eiichi, Hamada, Hiroaki, Maruyama, Toshiharu, Nakayama, Tomohiro
Format: Article
Language:English
Subjects:
Acute phase substances
Adult
Aged
Aged, 80 and over
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
C-Reactive Protein - metabolism
Case-Control Studies
Chronic renal failure
ELISA
Emergency and intensive care: renal failure. Dialysis management
Enzyme-Linked Immunosorbent Assay
Female
General aspects
haemodialysis
Hemodialysis
Humans
innate immunity
Intensive care medicine
Kidney Failure, Chronic - blood
Male
mannan
Mannose-binding lectin
Mannose-Binding Lectin - blood
Mannose-Binding Lectin - metabolism
Medical sciences
Middle Aged
Nephrology. Urinary tract diseases
Nephropathies. Renovascular diseases. Renal failure
Oligomerization
Pathogens
Renal Dialysis
Renal failure
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Summary:Eur J Clin Invest 2010; 40 (10): 865–873 Introduction  Mannose‐binding lectin (MBL) plays an important role in first‐line host defence against pathogens via the lectin pathway. The binding affinity for ligands is greatly increased by oligomerization, although the basic triplet does not bind solid phase mannan and cannot activate complement. Besides, MBL is a positive acute‐phase protein. In this study, we examined the relationship between oligomer and functional serum MBL in chronic renal failure patients who were either uraemic [Pre‐haemodialysis (pre‐HD) patients], or who were receiving maintenance haemodialysis treatment (HD patients). Materials and methods  This study included a total of 20 Pre‐HD patients, 130 HD patients and 28 healthy subjects. The oligomer and functional serum MBL levels were measured using enzyme‐linked immunosorbent assays established previously. Results  The median serum functional MBL levels were significantly reduced in both Pre‐HD and HD patients compared with healthy subjects (P 
ISSN:0014-2972
1365-2362
DOI:10.1111/j.1365-2362.2010.02325.x