mini review of MAR-binding proteins

Genomic DNA encompasses several levels of organization, the nuclear matrix mediates the formation of DNA loop domains that are anchored to matrix attachment regions (MARs). By means of specific interaction with MAR binding proteins (MARBPs), MAR plays an important regulation role in enhancing transg...

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Bibliographic Details
Published in:Molecular biology reports 2010-10, Vol.37 (7), p.3553-3560
Main Authors: Wang, Tian-Yun, Han, Zhong-Min, Chai, Yu-Rong, Zhang, Jun-He
Format: Article
Language:English
Subjects:
Algae
Animal Anatomy
Animal Biochemistry
Animals
Apoptosis
Binding sites
Biomedical and Life Sciences
Chromosomes
DNA
Gene expression
genomics
Histology
Humans
Life Sciences
MAR-binding proteins (MARBPs)
Matrix attachment region (MAR)
Matrix Attachment Region Binding Proteins - chemistry
Matrix Attachment Region Binding Proteins - genetics
Matrix Attachment Region Binding Proteins - metabolism
matrix attachment regions
Molecular biology
Morphology
nuclear matrix
Proteins
Replication origins
Reviews
Transgenes
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Summary:Genomic DNA encompasses several levels of organization, the nuclear matrix mediates the formation of DNA loop domains that are anchored to matrix attachment regions (MARs). By means of specific interaction with MAR binding proteins (MARBPs), MAR plays an important regulation role in enhancing transgene expression, decreasing expression variation among individuals of different transformants and serving as the replication origin. Through these years, some MARBPs have been identified and characterized from humans, plants, animals and algae so far and the list is growing. Most of MARBPs exist in a co-repressor/co-activator complex and involve in chromosome folding, regulation of gene expression, influencing cell development and inducing cell apoptosis. This review covers recent advances that have contributed to our understanding of MARBPs.
ISSN:0301-4851
1573-4978
DOI:10.1007/s11033-010-0003-8