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Activities of essential oils in the inhibition of Candida albicans and Candida dubliniensis germ tube formation
To investigate the effects of essential oils extracted from some spices in the inhibition of germ tube formation on Candida albicans and C. dubliniensis. The susceptibility of C. albicans fluconazole-susceptible ( n = 30), Candida albicans fluconazole-resistant ( n = 30) and C. dubliniensis fluconaz...
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Published in: | Journal de mycologie médicale 2010-09, Vol.20 (3), p.185-189 |
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Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
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Online Access: | Get full text |
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Summary: | To investigate the effects of essential oils extracted from some spices in the inhibition of germ tube formation on
Candida albicans and
C. dubliniensis.
The susceptibility of
C. albicans fluconazole-susceptible (
n
=
30),
Candida albicans fluconazole-resistant (
n
=
30) and
C. dubliniensis fluconazole-susceptible (
n
=
30) isolates to essential oils extracted from spices were evaluated through the inhibition of germ tube formation assay.
The minimum essential oil concentration able to inhibit germ tube formation ranged from 66.07
μg/ml (oregano) to above 3200
μg/ml (rosemary). Furthermore, the profile of activity was the same for three groups of fungi: oregano
>
Mexican oregano
>
thyme
>
cinnamon
>
ginger
>
basil
>
sage
>
rosemary.
C. albicans fluconazole-susceptible were more susceptible than
C. albicans fluconazole-resistant, requiring lower concentrations of essential oils to inhibit germ tube, whereas
C. albicans was more susceptible than
C. dubliniensis.
étudier les effets de certaines huiles essentielles sur l’inhibition de la formation du tube germinatif chez
C. albicans et
C. dubliniensis.
La sensibilité de
C. albicans fluconazole-sensibles (
n
=
30),
C. albicans fluconazole-résistant (
n
=
30) et
C. dubliniensis fluconazole-sensibles (
n
=
30) à diverses huiles essentielles a été évaluée par inhibition de la formation de tube germinatif.
La concentration minimale d’huile essentielle capable d’inhiber la formation de tube germinatif variait de 66,07
μg/ml (origan) à plus de 3200
μg/ml (romarin). En outre, le profil d’activité est le même pour trois groupes de champignons : origan
>
origan mexicain
>
thym
>
cannelle
>
gingembre
>
basilic
>
sauge
>
romarin.
Les souches de
C. albicans sensibles au fluconazole étaient plus vulnérables que les souches résistantes au fluconazole, nécessitant de plus faibles concentrations d’huiles essentielles pour inhiber tube germinatif. Par ailleurs, les souches de
C. albicans ont été plus sensibles que celles de
C. dubliniensis. |
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ISSN: | 1156-5233 1773-0449 |
DOI: | 10.1016/j.mycmed.2010.06.003 |