Oral administration of sodium selenite minimizes cisplatin toxicity on proximal tubules of rats

Cisplatin (c-DDP) is a widely used antineoplastic drug whose main side effect is nephrotoxicity. Selenium, administered intravenously or intraperitoneally, has been shown to provided protection against c-DDP-induced nephrotoxicity in rats. In the present study, the protective effect of orally admini...

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Bibliographic Details
Published in:Biological trace element research 2001-12, Vol.83 (3), p.251-262
Main Authors: Camargo, S M, Francescato, H D, Lavrador, M A, Bianchi, M L
Format: Article
Language:English
Subjects:
Acetylglucosaminidase - metabolism
Administration, Oral
Animals
Antineoplastic Agents - toxicity
Body Weight - drug effects
Cisplatin - toxicity
Creatinine - metabolism
Isoenzymes - metabolism
Kidney Tubules, Proximal - drug effects
Kidney Tubules, Proximal - metabolism
Kidney Tubules, Proximal - pathology
Male
Rats
Rats, Wistar
Renal function
Rodents
Selenium
Side effects
Sodium
Sodium Selenite - pharmacology
Toxicity
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Summary:Cisplatin (c-DDP) is a widely used antineoplastic drug whose main side effect is nephrotoxicity. Selenium, administered intravenously or intraperitoneally, has been shown to provided protection against c-DDP-induced nephrotoxicity in rats. In the present study, the protective effect of orally administered sodium selenite on c-DDP toxicity was further examined. Animals treated with c-DDP alone showed increased urinary volume, decreased creatinine clearance (GFR), and a rise in urinary N-acetyl-(beta-D-glucosaminidase) (NAG) isoenzyme B activity. When sodium selenite was given prior to c-DDP, rats showed less GFR decline, delayed urinary volume increases, and no urinary NAG isoenzyme B activity increment. It is suggested that a single oral dose of sodium selenite given prior to c-DDP administration, although not preventing deterioration of renal function, partially protects rats from early proximal tubular injury.
ISSN:0163-4984
0163-4984
1559-0720
DOI:10.1385/BTER:83:3:251