Breast cancer genomics: normal tissue and cancer markers

Mammography is a powerful screening tool for early detection of breast cancer, but it has limitations in terms of both specificity and sensitivity. Imaging tools such as MRI that complement mammography are too costly to serve as first‐line screens. Recently, progress has been made on blood markers,...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2010-10, Vol.1210 (1), p.78-85
Main Authors: Schummer, Michèl, Beatty, David, Urban, Nicole
Format: Article
Language:English
Subjects:
aggressive breast cancer
Biomarkers, Tumor - analysis
Biomarkers, Tumor - blood
Biomarkers, Tumor - genetics
Blood
Breast cancer
Breast Neoplasms - epidemiology
Breast Neoplasms - genetics
Breast Neoplasms - pathology
Breast Neoplasms - therapy
cancer environment
cancer environment, aggressive breast cancer
early detection
Female
Genetic Markers - genetics
Genomics
Humans
Magnetic Resonance Imaging
Malignancy
Mammography
Mass Screening
Medical research
MicroRNAs - genetics
miRNA
normal breast tissue
Reference Values
RNA, Neoplasm - genetics
Treatment Outcome
United States - epidemiology
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Summary:Mammography is a powerful screening tool for early detection of breast cancer, but it has limitations in terms of both specificity and sensitivity. Imaging tools such as MRI that complement mammography are too costly to serve as first‐line screens. Recently, progress has been made on blood markers, particularly microRNAs and proteins. There are new methods for protein marker discovery directly in blood, but they are limited in the number of patients that can be examined. An alternative is to discover markers as transcripts in tissues, followed by development of blood protein tests for those that perform best. To identify genes that are overexpressed in malignancy it is paramount to include normal control tissues from healthy individuals. Here we report the identification of potential breast cancer markers, including some that are overexpressed in aggressive disease.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.2010.05803.x