Chlamydia pneumoniae infection is associated with elevated body mass index in young men

Chlamydia pneumoniae infection is said to be associated with obesity. We studied the association between C. pneumoniae infection and inflammation and increased BMI in 891 Finnish military recruits. IgG seropositivity in arrival and departure serum samples during 6–12 months of military service was c...

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Bibliographic Details
Published in:Epidemiology and infection 2010-09, Vol.138 (9), p.1267-1273
Main Authors: RANTALA, A., LAJUNEN, T., JUVONEN, R., BLOIGU, A., PALDANIUS, M., SILVENNOINEN-KASSINEN, S., PEITSO, A., VAINIO, O., LEINONEN, M., SAIKKU, P.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Antibodies
Asthma
Asthma - epidemiology
Bacteriology
Biological and medical sciences
Body fat
Body Mass Index
C-reactive protein
C-Reactive Protein - metabolism
Cardiovascular disease
Chi-Square Distribution
Chlamydia
Chlamydophila Infections - blood
Chlamydophila Infections - epidemiology
Chlamydophila Infections - microbiology
Chlamydophila pneumoniae
Chlamydophila pneumoniae - isolation & purification
Conscription
Education
Finland
Fundamental and applied biological sciences. Psychology
Humans
Immunoglobulin G - blood
Infections
Inflammation
Inflammation - blood
Insulin resistance
Logistic Models
Male
Microbiology
Microorganisms
Military service
Miscellaneous
Obesity
Obesity - epidemiology
Overweight
Predisposing factors
Respiratory infection
Risk Factors
Smoking - epidemiology
Surveys and Questionnaires
Tumor necrosis factor-TNF
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Summary:Chlamydia pneumoniae infection is said to be associated with obesity. We studied the association between C. pneumoniae infection and inflammation and increased BMI in 891 Finnish military recruits. IgG seropositivity in arrival and departure serum samples during 6–12 months of military service was considered as persistence of antibodies and a possible indication of chronic infection. Persistently high C-reactive protein (CRP) level (elevated on arrival and departure) (OR 2·2, 95% CI 1·3–3·9), and persistent C. pneumoniae antibodies (OR 2·1, 95% CI 1·5–2·8) were significant risk factors for overweight (BMI ⩾25 kg/m2). In addition, those who had persistent antibodies and persistently elevated CRP levels, or those who had either of them, had a significantly higher BMI (kg/m2) compared to those who had neither of them (25·8 vs. 24·6 vs. 23·5, respectively; P
ISSN:0950-2688
1469-4409
DOI:10.1017/S0950268809991452