A nationwide survey for prevalence of hepatitis E virus antibody in qualified blood donors in Japan

Background and Objectives  In previous studies, we reported the transmission of hepatitis E virus (HEV) by transfusion, and the frequent detection of HEV markers in Japanese blood donors with elevated ALT levels. For the current study, we carried out a nationwide survey of the prevalence of IgG anti...

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Bibliographic Details
Published in:Vox sanguinis 2010-11, Vol.99 (4), p.307-313
Main Authors: Takeda, H., Matsubayashi, K., Sakata, H., Sato, S., Kato, T., Hino, S., Tadokoro, K., Ikeda, H.
Format: Article
Language:English
Subjects:
Age Factors
Blood & organ donations
Blood Donors
Data Collection
Disease transmission
Donor Selection
Enzyme-linked immunosorbent assay
Enzyme-Linked Immunosorbent Assay - methods
Epidemiology
Female
Hepatitis
Hepatitis Antibodies - blood
hepatitis E
Hepatitis E - blood
Hepatitis E - epidemiology
Hepatitis E virus
HEV antibody
Humans
Immunoglobulin G
Immunoglobulin G - blood
Infection
Japan - epidemiology
Male
Prevalence
screening
Seroepidemiologic Studies
Sex Factors
Transfusion
Viruses
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Summary:Background and Objectives  In previous studies, we reported the transmission of hepatitis E virus (HEV) by transfusion, and the frequent detection of HEV markers in Japanese blood donors with elevated ALT levels. For the current study, we carried out a nationwide survey of the prevalence of IgG anti‐HEV in qualified blood donors throughout Japan. Materials and Methods  The 12 600 samples from qualified blood donors were collected from seven blood centres (1800 per centre) representing nearly all regions of Japan. Samples were from age‐ and sex‐matched blood donors who tested negative for all the current blood screening tests. The samples were screened using the in‐house IgG anti‐HEV ELISA. Sequentially, the positive samples were tested by the commercial IgG anti‐HEV ELISA. Results  Of 12 600 samples, 431 (3·4%) were regarded as positive for IgG anti‐HEV. The prevalence of IgG anti‐HEV was higher in eastern Japan (5·6%) than in western Japan (1·8%) (P 
ISSN:0042-9007
1423-0410
DOI:10.1111/j.1423-0410.2010.01362.x