Risk factor analysis for pneumococcal meningitis in adults with invasive pneumococcal infection

Pneumococcal meningitis is a subgroup of invasive pneumococcal disease with a case-fatality rate of up to 30% and long-term sequelae in more than 50% of cases in adults in developed countries. We aimed to determine risk factors for this particular form of pneumococcal disease. We conducted a prospec...

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Bibliographic Details
Published in:Epidemiology and infection 2010-09, Vol.138 (9), p.1353-1358
Main Authors: BURCKHARDT, I., BURCKHARDT, F., VAN DER LINDEN, M., HEEG, C., REINERT, R. R.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age
Aged
Antibiotics
Bacterial diseases
Bacteriology
Biological and medical sciences
Blood-brain barrier
Epidemiology
Fatalities
Female
Fundamental and applied biological sciences. Psychology
Gender
Germany - epidemiology
Human bacterial diseases
Humans
Immunization
Infectious diseases
Laboratories
Linear Models
Macrolides
Male
Medical sciences
Meningitis
Meningitis, Pneumococcal - epidemiology
Meningitis, Pneumococcal - microbiology
Microbial Sensitivity Tests
Microbiology
Middle Aged
Miscellaneous
multiple logistic regression
Multivariate analysis
Nervous system diseases
Other infections
P values
Pathogens
Penicillin
Pneumococcal Infections - epidemiology
Pneumococcal Infections - microbiology
Pneumococcal meningitis
pneumococci
Pneumonia
population study
Predisposing factors
Prospective Studies
risk factor
Risk Factors
Seasons
Serotyping
Sex Factors
Staphylococcal infections, streptococcal infections, pneumococcal infections
Statistical analysis
Streptococcus infections
Streptococcus pneumoniae
Streptococcus pneumoniae - classification
Streptococcus pneumoniae - isolation & purification
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Summary:Pneumococcal meningitis is a subgroup of invasive pneumococcal disease with a case-fatality rate of up to 30% and long-term sequelae in more than 50% of cases in adults in developed countries. We aimed to determine risk factors for this particular form of pneumococcal disease. We conducted a prospective population-based laboratory study of invasive pneumococcal disease in adults in North-Rhine-Westphalia, Germany from February 2001 to August 2006. All isolates underwent serotyping and susceptibility testing at the National Reference Centre for Streptococci in Aachen, Germany. Data were analysed using multiple linear regression. A total of 1043 isolates from bacteraemia and 131 isolates from meningitis were included into the study. Serotype 23F and being female were independent risk factors for pneumococcal meningitis. Being ⩾60 years and serotype 1 were associated with a reduced odds ratio. Season, penicillin and macrolide resistance were not statistically associated with CNS involvement.
ISSN:0950-2688
1469-4409
DOI:10.1017/S0950268809991683