Influence of methionine and zinc on liver collagen in molybdenotic rats: relationship with lipid peroxidation

Protective effects of methionine and zinc on collagenesis in the liver of molybdenotic rats have been studied during present investigations. Further, the relationship between two important pathobiological phenomena (viz. lipid peroxidation and collagenesis) has also been examined. Biological observa...

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Bibliographic Details
Published in:Biological trace element research 2000-01, Vol.73 (1), p.85-92
Main Authors: Rana, S V, Chauhan, A
Format: Article
Language:English
Subjects:
Animals
Collagen - metabolism
Hydroxyproline - urine
Lipid Peroxidation
Liver
Liver - metabolism
Male
Methionine - metabolism
Methionine - pharmacology
Molybdenum
Molybdenum - pharmacology
Molybdenum - toxicity
Peroxidation
Rats
Rats, Wistar
Reactive Oxygen Species
Rodents
Zinc
Zinc - metabolism
Zinc - pharmacology
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Summary:Protective effects of methionine and zinc on collagenesis in the liver of molybdenotic rats have been studied during present investigations. Further, the relationship between two important pathobiological phenomena (viz. lipid peroxidation and collagenesis) has also been examined. Biological observations suggest that cotreatment with methionine only improves the growth of molybdenotic rats; however, the hepatosomatic index improved in rats supplemented with both methionine and zinc. Administration of methionine and zinc to molybdenum-fed rats decreased liver collagen. Results on urinary hydroxyproline support these observations. Lipid peroxidation was also inhibited in the liver of protected rats. We suggest that collagenesis can be controlled by inhibiting the generation of reactive oxygen species. An improvement in liver function in rats protected with methionine and zinc has also been suggested.
ISSN:0163-4984
0163-4984
1559-0720
DOI:10.1385/bter:73:1:85