The genome of BCJA1c: a bacteriophage active against the alkaliphilic bacterium, Bacillus clarkii

The sequence of the genome of the first alkaliphilic bacteriophage has been determined. Temperate phage BCJA1 possesses a terminally redundant genome of approximately 41 kb, with a mol% G + C content of 41.7 and 59 genes arranged predominantly into two divergent transcriptons. The integrase gene of...

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Bibliographic Details
Published in:Extremophiles : life under extreme conditions 2005-04, Vol.9 (2), p.99-109
Main Authors: KROPINSKI, Andrew M, HAYWARD, Melissa, AGNEW, M. Dorothy, JARRELL, Ken F
Format: Article
Language:English
Subjects:
Bacillus
Bacillus - metabolism
Bacillus - virology
Bacillus clarkii
Bacillus Phages - metabolism
Bacteria
Bacteriology
Bacteriophages - genetics
Base Sequence
Biological and medical sciences
DNA Replication
DNA, Complementary - metabolism
Frameshift Mutation
Fundamental and applied biological sciences. Psychology
Genome, Viral
Hydrogen-Ion Concentration
Integrases - metabolism
Lysogeny
Microbiology
Miscellaneous
Models, Genetic
Molecular Sequence Data
Open Reading Frames
Protein Conformation
Recombination, Genetic
Ribosomes - metabolism
Sequence Analysis, DNA
Space life sciences
Streptococcus
Streptococcus - metabolism
Temperature
Transcription, Genetic
Virology
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Summary:The sequence of the genome of the first alkaliphilic bacteriophage has been determined. Temperate phage BCJA1 possesses a terminally redundant genome of approximately 41 kb, with a mol% G + C content of 41.7 and 59 genes arranged predominantly into two divergent transcriptons. The integrase gene of this phage is unique in that it contains a ribosomal slippage site. While this type of translational regulation occurs in the synthesis of transposase, this is the first time that it has been observed in a bacteriophage integrase. The DNA replication, recombination, packaging, and morphogenesis proteins show their greatest sequence similarity to phages and prophages from the genus Streptococcus. Host specificity, lysin, and lysogeny maintenance functions are most closely related to genes from Bacillus species.
ISSN:1431-0651
1433-4909
DOI:10.1007/s00792-004-0425-0