Oral administration of Lactobacillus acidophilus induces IL-12 production in spleen cell culture of BALB/c mice bearing transplanted breast tumour

Lactic acid bacteria can affect the maturation of immune cells and their products not only in the gut but also on the systemic immune organs such as lymph nodes and spleen. In the present work, we studied the effects of oral administration of Lactobacillus acidophilus on the immune responses of BALB...

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Bibliographic Details
Published in:British journal of nutrition 2010-07, Vol.104 (2), p.227-232
Main Authors: Yazdi, Mohammad Hossein, Soltan Dallal, Mohammad Mehdi, Hassan, Zuhair Mohammad, Holakuyee, Marzieh, Agha Amiri, Solmaz, Abolhassani, Mohsen, Mahdavi, Mehdi
Format: Article
Language:English
Subjects:
Adenocarcinoma - immunology
Administration, Oral
Animals
Bacteria
Biological and medical sciences
Breast cancer
Breasts
Cellular biology
Centrifugation
Feeding. Feeding behavior
Female
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation - drug effects
Hypersensitivity
Immune system
Immunomodulation
Interleukin-12 - genetics
Interleukin-12 - metabolism
Lactobacillus acidophilus
Lymph nodes
Mammary Neoplasms, Animal - immunology
Mice
Mice, Inbred BALB C
Neoplasm Transplantation
Nutritional Immunology
Probiotics
Probiotics - pharmacology
Rodents
Spleen
Spleen - cytology
Spleen - immunology
Tumors
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:Lactic acid bacteria can affect the maturation of immune cells and their products not only in the gut but also on the systemic immune organs such as lymph nodes and spleen. In the present work, we studied the effects of oral administration of Lactobacillus acidophilus on the immune responses of BALB/c mice bearing transplanted breast tumour. Two groups of female inbred BALB/c mice, each containing nine mice as test and control, were used. The L. acidophilus ATCC4356 strain was inoculated in DeMan–Rogosa–Sharpe broth and cultivated for 24 h at 37°C. Then, it was collected by centrifugation, and was washed and suspended in PBS. Afterwards, 0·5 ml/d of this suspension, which contained 2·7 × 108 colony forming units/ml of bacteria, was orally administered to the mice by gavage, 14 d before tumour transplantation and 30 d after that with 3-d intervals. Similar to the test mice, the control mice received an equal volume of PBS. The results showed that oral administration of L. acidophilus increased the production of IL-12 (P 
ISSN:0007-1145
1475-2662
DOI:10.1017/S0007114510000516