Molecular characterization of SAT 2 foot-and-mouth disease virus from post-outbreak slaughtered animals: implications for disease control in Uganda

In Uganda, limiting the extent of foot-and-mouth disease (FMD) spread during outbreaks involves short-term measures such as ring vaccination and restrictions of the movement of livestock and their products to and from the affected areas. In this study, the presence of FMD virus RNA was investigated...

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Bibliographic Details
Published in:Epidemiology and infection 2010-08, Vol.138 (8), p.1204-1210
Main Authors: BALINDA, S. N., BELSHAM, G. J., MASEMBE, C., SANGULA, A. K., SIEGISMUND, H. R., MUWANIKA, V. B.
Format: Article
Language:English
Subjects:
Animals
Base Composition
Base Sequence
Biological and medical sciences
Capsid Proteins - genetics
Cattle
Disease control
Disease Outbreaks - prevention & control
Disease Outbreaks - veterinary
DNA polymerase
Epidemics
FMD control
Foot & mouth disease
Foot-and-Mouth Disease - epidemiology
Foot-and-Mouth Disease - prevention & control
Foot-and-Mouth Disease - virology
Foot-and-mouth disease virus
Foot-and-Mouth Disease Virus - genetics
Foot-and-Mouth Disease Virus - isolation & purification
Fundamental and applied biological sciences. Psychology
Microbiology
Miscellaneous
Molecular Sequence Data
Phylogenetics
Phylogeny
Quarantine - veterinary
Reverse Transcriptase Polymerase Chain Reaction
RNA, Viral
SAT 2
Sequence Alignment
sequence divergence
Uganda - epidemiology
Virology
Viruses
Viruses and animals
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Summary:In Uganda, limiting the extent of foot-and-mouth disease (FMD) spread during outbreaks involves short-term measures such as ring vaccination and restrictions of the movement of livestock and their products to and from the affected areas. In this study, the presence of FMD virus RNA was investigated in cattle samples 3 months after FMD quarantine measures had been lifted following an outbreak in 2004. Oropharyngeal tissue samples were obtained from 12 cattle slaughtered in a small town abattoir in Kiboga. FMD virus RNA was detected by diagnostic RT–PCR in nine of the 12 tissue samples. Part of the coding region for the capsid protein VP1 was amplified and sequenced. All samples were identified as belonging to the SAT 2 serotype. The implications for FMD control of both virus introduction into Uganda and the presence of carrier animals following outbreaks are discussed.
ISSN:0950-2688
1469-4409
DOI:10.1017/S0950268809991427