Circadian rhythm of bone formation biomarkers in serum of dromedary camels

The circadian rhythm of biomarkers of bone formation including osteocalcin and bone alkaline phosphatase (BAP) was studied in the serum of dromedary camels. Blood samples were collected every 60 min for 24 h from 10 healthy adult female camels. ELISA was used to determine the concentrations of serum...

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Bibliographic Details
Published in:Research in veterinary science 2010-12, Vol.89 (3), p.455-459
Main Author: Al-Sobayil, F.A.
Format: Article
Language:English
Subjects:
Alkaline Phosphatase - blood
Alkaline Phosphatase - physiology
Animals
Biomarkers
Biomarkers - blood
Biomarkers - metabolism
blood chemistry
blood sampling
blood serum
Bone alkaline phosphatase
Bone biomarkers
Bone density
bone formation
Bones
Camelus - blood
Camelus - metabolism
Camelus - physiology
Circadian rhythm
Circadian Rhythm - physiology
dromedaries
Enzyme-Linked Immunosorbent Assay - veterinary
Female
Medical imaging
Osteocalcin
Osteocalcin - blood
Osteocalcin - physiology
Osteogenesis - physiology
Osteoporosis
Phosphate esters
Serum
Veterinary medicine
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Summary:The circadian rhythm of biomarkers of bone formation including osteocalcin and bone alkaline phosphatase (BAP) was studied in the serum of dromedary camels. Blood samples were collected every 60 min for 24 h from 10 healthy adult female camels. ELISA was used to determine the concentrations of serum osteocalcin and BAP. The results showed a marked fluctuation in the concentration of osteocalcin during the 24 h period with minimum and maximum levels at 13:00 (01:00 pm) and 18:00 (06:00 pm), respectively. Slight fluctuation was observed in the concentration of BAP with minimum and maximum levels at 01:00 am and 12:00 pm, respectively. The correlation between the two biomarkers was weak. It was concluded that it is important to fix the time of blood sampling for analysis of osteocalcin concentrations, but not for BAP.
ISSN:0034-5288
1532-2661
DOI:10.1016/j.rvsc.2010.03.024