Interrelation between Malonyl Dialdehyde-Dependent Modification and Cholesterol Content in Low-Density Lipoproteins

Epidemiological study of an independent representative sample of population revealed a strong positive correlation between the content of oxidized (MDA-modified) LDL and concentration of atherosclerosis biomarkers (total cholesterol and LDL cholesterol) in blood plasma from 348 probands. The correla...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2010-08, Vol.149 (2), p.184-186
Main Authors: Tikhaze, A. K., Viigimaa, M., Konovalova, G. G., Kumskova, E. M., Abina, E. A., Zemtsovskaya, G., Yanushevskaya, E. V., Vlasik, T. N., Lankin, V. Z.
Format: Article
Language:English
Subjects:
Adult
Atherosclerosis
Atherosclerosis - blood
Biomarkers - blood
Biomedical and Life Sciences
Biomedicine
Blood Glucose
Blood lipids
Cell Biology
Cholesterol - blood
Cholesterol, LDL - blood
Diabetes
Diabetes Mellitus - blood
Epidemiology
Estonia
Glyoxal - blood
Humans
Immunochemistry
Internal Medicine
Laboratory Medicine
Lipoproteins, LDL - metabolism
Low density lipoproteins
Male
Malondialdehyde - blood
Malondialdehyde - metabolism
Middle Aged
Oxidation-Reduction
Pathology
Pyruvaldehyde - blood
Spectrophotometry
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Summary:Epidemiological study of an independent representative sample of population revealed a strong positive correlation between the content of oxidized (MDA-modified) LDL and concentration of atherosclerosis biomarkers (total cholesterol and LDL cholesterol) in blood plasma from 348 probands. The correlation between these parameters was more significant in atherosclerotic patients, but was less pronounced in probands with diabetes mellitus. The correlation between the concentration of atherosclerosis markers and content of MDA was absent in probands with diabetes mellitus. These data attest to the presence of LDL-modifying agents differing from MDA ( e.g. , glyoxal and methylglyoxal) in the blood of diabetes mellitus patients. We conclude that the content of MDA-modified LDL can serve as an additional biomarker of atherosclerosis.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-010-0903-6