Expression of Early Immune Response Genes during Physical Exercise

Study by means of expression profiling with Human GeneChip ST1.0 microchips (Affymetrix) revealed 10 early immune response genes, whose expression was modified after short-term intense physical exercise. They include genes for immunoglobulin-like receptors of natural killer cell, genes for IL-2Rβ an...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2010-07, Vol.149 (1), p.89-92
Main Authors: Shleptsova, V. A, Trushkin, E. V, Bystryh, O. A, Davydov, J. I, Obrazcova, N. P, Grebenuk, E. S, Tonevitsky, A. G
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Cell Biology
Exercise
Exercise - physiology
Gene expression
Gene Expression Regulation - immunology
Gene Expression Regulation - physiology
Genes
Granzymes - metabolism
Humans
Immune response
immune system
Immunoglobulins
Interleukin-2 Receptor beta Subunit - metabolism
Internal Medicine
Laboratory Medicine
Male
natural killer cells
Oligonucleotide Array Sequence Analysis
Pathology
Perforin
Pore Forming Cytotoxic Proteins - metabolism
Receptors, Interleukin-18 - metabolism
Receptors, Natural Killer Cell - genetics
Receptors, Natural Killer Cell - metabolism
Sports Medicine
Young Adult
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Summary:Study by means of expression profiling with Human GeneChip ST1.0 microchips (Affymetrix) revealed 10 early immune response genes, whose expression was modified after short-term intense physical exercise. They include genes for immunoglobulin-like receptors of natural killer cell, genes for IL-2Rβ and IL-18RAP receptors, and two genes for functional proteins (perforin 1 and granzyme B) that provide the cytotoxic potential of killer cells. Possible mechanisms of stimulation, activation of the receptor apparatus, and cytotoxic effect on natural killer cells are evaluated under conditions of physical exercise.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-010-0883-6