Long-term effects of the daily wear of senofilcon A silicone hydrogel contact lenses on corneal and conjunctival tissues

The objective of the investigation was to show that, because of their overall properties, Acuvue ® Oasys™ with Hydraclear ® Plus brand (senofilcon A) silicone hydrogel contact lenses achieve excellent ocular tissue tolerance during long-term daily wear. The 2-year investigation was a prospective dai...

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Bibliographic Details
Published in:Optometry (Saint Louis, Mo.) Mo.), 2010-12, Vol.81 (12), p.680-687
Main Authors: Guillon, Michel, Maïssa, Cécile
Format: Article
Language:English
Subjects:
Adult
Conjunctiva - blood supply
Conjunctival Diseases - etiology
Conjunctival Diseases - prevention & control
Conjunctival staining
Contact Lenses, Extended-Wear - adverse effects
Corneal Diseases - etiology
Corneal Diseases - prevention & control
Corneal staining
Daily wear
Female
Humans
Hydrogels
Hyperemia
Hyperemia - etiology
Hyperemia - prevention & control
Limbus Corneae - blood supply
Male
Prospective Studies
Silicone hydrogel
Silicones
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Summary:The objective of the investigation was to show that, because of their overall properties, Acuvue ® Oasys™ with Hydraclear ® Plus brand (senofilcon A) silicone hydrogel contact lenses achieve excellent ocular tissue tolerance during long-term daily wear. The 2-year investigation was a prospective daily wear analysis of Acuvue ® Oasys™ with Hydraclear ® Plus (senofilcon A) silicone hydrogel contact lenses replaced every 2 weeks and used in conjunction with a representative range of care systems. The 2-year results compared with the subjects' baseline ocular status on entering the study revealed: • For new wearers, there was no change in the limbal zone and significant improvement in the bulbar area, both in terms of hyperemia and staining and in corneal staining. • For established contact lens wearers, there was an improvement in all 3 characteristics. The quantification of the effects on the ocular tissues of 2 years of daily wear of senofilcon A, by mainly previously successful daily soft contact lens wearers, showed an excellent biocompatibility. The results support the hypothesis that senofilcon A contact lenses, when worn on a 2-week daily wear regimen, maintain excellent long-term ocular tissue tolerance.
ISSN:1529-1839
1558-1527
DOI:10.1016/j.optm.2009.10.015