Characteristics of zero-quantum correlation spectroscopy in MAS NMR experiments

Zero-quantum coherence generation and reconversion in magic-angle spinning solid-state NMR is analyzed. Two methods are discussed based on implementations using symmetry-based pulse sequences that utilize either isotropic J couplings or dipolar couplings. In either case, the decoupling of abundant p...

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Bibliographic Details
Published in:Journal of magnetic resonance (1997) 2010-12, Vol.207 (2), p.197-205
Main Authors: Köneke, Stephanie G., van Beek, Jacco D., Ernst, Matthias, Meier, Beat H.
Format: Article
Language:English
Subjects:
Analogies
Arginine - chemistry
Carbon Monoxide - chemistry
Carbon Radioisotopes
Coherence
Correlation
Couplings
Decoupling
Electronics
Magic-angle spinning
Magnetic Resonance Spectroscopy - methods
Molecular Conformation
Multi-quantum coherence
Nitrogen Radioisotopes
NMR
Nuclear magnetic resonance
Phenylalanine - chemistry
Quantum Theory
Recoupling
Spectra
Spectral resolution
Spectroscopy
Ubiquitin - chemistry
Valine - chemistry
Zero-quantum coherence
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Summary:Zero-quantum coherence generation and reconversion in magic-angle spinning solid-state NMR is analyzed. Two methods are discussed based on implementations using symmetry-based pulse sequences that utilize either isotropic J couplings or dipolar couplings. In either case, the decoupling of abundant proton spins plays a crucial role for the efficiency of the zero-quantum generation. We present optimized sequences for measuring zero-quantum single-quantum correlation spectra in solids, achieving an efficiency of 50% in ubiquitin. The advantages and disadvantages of zero-quantum single-quantum over single-quantum single-quantum correlation spectroscopy are explored, and similarities and differences with double-quantum single-quantum correlation spectroscopy are discussed. Finally, possible application of zero-quantum single-quantum experiments to polypeptides, where it can lead to better spectral resolution is investigated using ubiquitin, where we find high efficiency and high selectivity, but also increased line widths in the MQ dimension.
ISSN:1090-7807
1096-0856
DOI:10.1016/j.jmr.2010.08.020