Efficient Syntheses of the Unknown Quinolino[2,3-c]cinnolines; Synthesis of Neocryptolepines

A facile, efficient, three-step protocol for the synthesis of the unknown quinolino[2,3-c]cinnoline 5 is introduced. In addition, a new approach for the preparation of the biologically active neocryptolepines 8 in good overall yields is described.

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Bibliographic Details
Published in:Organic letters 2010-12, Vol.12 (23), p.5502-5505
Main Authors: Haddadin, Makhluf J, Zerdan, Raghida M. Bou, Kurth, Mark J, Fettinger, James C
Format: Article
Language:English
Subjects:
Alkaloids - chemical synthesis
Crystallography, X-Ray
Heterocyclic Compounds, 2-Ring - chemical synthesis
Models, Molecular
Molecular Structure
Oxidation-Reduction
Quinolines - chemical synthesis
Quinolines - chemistry
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Description
Summary:A facile, efficient, three-step protocol for the synthesis of the unknown quinolino[2,3-c]cinnoline 5 is introduced. In addition, a new approach for the preparation of the biologically active neocryptolepines 8 in good overall yields is described.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol102376a