Are glucocorticoids auto– and/or paracrine factors in early bovine embryo development and implantation?

SUMMARY We determined the transcript content of three genes involved in the metabolism of glucocorticoids (GC) in bovine in vitro fertilized embryos (2–blastomere stage until hatched blastocyst), trophoblast as well as the oviduct (Day 2–4 of the estrous cycle) and endometrium (Day 16 of the cycle a...

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Published in:Reproductive biology 2010-11, Vol.10 (3), p.249-256
Main Authors: Siemieniuch, Marta J, Majewska, Magdalena, Takahashi, Masashi, Sakatani, Miki, Łukasik, Karolina, Okuda, Kiyoshi, Skarzynski, Dariusz J
Format: Article
Language:English
Subjects:
Animals
Autocrine Communication
cattle
Cattle - embryology
embryo
Embryo Implantation
endometrium
Endometrium - enzymology
Female
glucocorticoids
Glucocorticoids - metabolism
Obstetrics and Gynecology
oviduct
Oviducts - enzymology
Paracrine Communication
Receptors, Glucocorticoid - metabolism
trophoblast
Trophoblasts - enzymology
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Summary:SUMMARY We determined the transcript content of three genes involved in the metabolism of glucocorticoids (GC) in bovine in vitro fertilized embryos (2–blastomere stage until hatched blastocyst), trophoblast as well as the oviduct (Day 2–4 of the estrous cycle) and endometrium (Day 16 of the cycle and pregnancy). Since mRNA expression of the glucocorticoid receptor and two enzymes responsible for GC production ( 11ß–HSD1 and 2) was demonstrated in the embryos in all pre–implantation stages as well as in the endometrium and oviduct, it is suggested that GC may serve as auto–/paracrine factors in the development of bovine pre–implantation embryos.
ISSN:1642-431X
DOI:10.1016/S1642-431X(12)60045-X