growing diversity and spectrum of action of myeloid‐derived suppressor cells

Myeloid‐derived suppressor cells (MDSC) are a heterogeneous population of myelomonocytic cells endowed with suppressive activity. MDSC expand and acquire suppressive functions in chronic inflammatory conditions, in particular in neoplastic disorders. As exemplified in two reports in this issue of th...

Full description

Saved in:
Bibliographic Details
Published in:European journal of immunology 2010-12, Vol.40 (12), p.3317-3320
Main Author: Mantovani, Alberto
Format: Article
Language:English
Subjects:
Animals
Antigens, Ly
Cell Differentiation
Cytotoxicity, Immunologic
Immunosuppression
Immunotherapy
Interleukin-1beta - immunology
Macrophages
Mice
Myeloid Cells - immunology
Myeloid‐derived suppressor cells
Neoplasms - immunology
Neoplasms - therapy
Neutrophils
Receptors, Cannabinoid - immunology
Tumor Escape
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Myeloid‐derived suppressor cells (MDSC) are a heterogeneous population of myelomonocytic cells endowed with suppressive activity. MDSC expand and acquire suppressive functions in chronic inflammatory conditions, in particular in neoplastic disorders. As exemplified in two reports in this issue of the European Journal of Immunology, progress has been made in defining MDSC‐inducing signals, MDSC phenotypic diversity and spectrum of action. These recent results provide a basis to better define the relationship of MDSC with the adaptive immune responses of mononuclear phagocytes and neutrophils and to exploit their function in a therapeutic setting.
ISSN:0014-2980
1521-4141
DOI:10.1002/eji.201041170