Dimethylarginines and Serotonin in the Blood of Spontaneously Hypertensive Rats

The serotoninergic system and nitric oxide system were studied in spontaneously hypertensive rats SHR and Wistar rats (control). The contents of serotonin, 5-hydroxyindoleacetic acid (serotonin metabolite), L-arginine, monomethylarginine, and asymmetric and symmetric dimethylarginines were measured...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2009-12, Vol.148 (6), p.849-851
Main Authors: Gilinsky, M. A, Latysheva, T. V, Petrakova, G. M
Format: Article
Language:English
Subjects:
Animals
Arginine - analogs & derivatives
Arginine - blood
Biomedical and Life Sciences
Biomedicine
Cell Biology
dimethylarginines
Hydroxyindoleacetic Acid - blood
hypertension
Internal Medicine
Laboratory Medicine
nitric oxide
Nitric Oxide - blood
Pathology
Rats
Rats, Inbred SHR
Rats, Wistar
serotonin
Serotonin - blood
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Summary:The serotoninergic system and nitric oxide system were studied in spontaneously hypertensive rats SHR and Wistar rats (control). The contents of serotonin, 5-hydroxyindoleacetic acid (serotonin metabolite), L-arginine, monomethylarginine, and asymmetric and symmetric dimethylarginines were measured in blood plasma. Serotonin content in hypertensive animals was much higher than in Wistar rats. No interstrain differences were found in the concentration of 5-hydroxyindoleacetic acid. The concentration of asymmetric dimethylarginine in SHR rats was higher than in Wistar rats. However, the concentration of monomethylarginine in SHR rats was lower than in Wistar rats. Our results and published data on the serotoninergic system indicate that SHR rats serve as a convenient model of hypertension.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-010-0833-3