Classic and Alternative Complement Cascades in Post-Traumatic Stress Disorder

Hemolytic activity of classic and alternative complement cascades and blood concentrations of TNF-α, IL-1β, and IL-6 were measured in patients with post-traumatic stress disorder. The results attest to hyperactivity of the classic complement cascade associated with elevated content of proinflammator...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2009-12, Vol.148 (6), p.859-861
Main Authors: Oganesyan, L. P, Mkrtchyan, G. M, Sukiasyan, S. H, Boyajyan, A. S
Format: Article
Language:English
Subjects:
Adult
Biomedical and Life Sciences
Biomedicine
Cell Biology
complement system
Enzyme-Linked Immunosorbent Assay
Female
Humans
Interleukin-1beta - blood
Interleukin-6 - blood
Internal Medicine
Laboratory Medicine
Male
Middle Aged
Pathology
post-traumatic stress disorder
pro-infl ammatory cytokines
Stress Disorders, Post-Traumatic - blood
Tumor Necrosis Factor-alpha - blood
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Summary:Hemolytic activity of classic and alternative complement cascades and blood concentrations of TNF-α, IL-1β, and IL-6 were measured in patients with post-traumatic stress disorder. The results attest to hyperactivity of the classic complement cascade associated with elevated content of proinflammatory cytokines and hypoactivation of the alternative complement cascade in patients with post-traumatic stress disorder in comparison with healthy individuals.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-010-0836-0