Concanavalin A Agglutination of Intestinal Cells from the Human Fetus

Concanavalin A markedly agglutinated isolated epithelial cells from the intestine of the human fetus but not from the intestine of the adult. Wheat germ agglutinin only moderately agglutinated cells from the intestine of an adult. These results extend the studies of concanavalin A agglutination of e...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1972-08, Vol.177 (4048), p.525-526
Main Author: Weiser, Milton M.
Format: Article
Language:English
Subjects:
Age Factors
Agglutination
Agglutination - drug effects
Animals
Cell adhesion
Cell membranes
Cells, Cultured - drug effects
Concanavalin A - pharmacology
Embryonic cells
Epithelial Cells
Epithelium - drug effects
Female
Fetus
Fetus - drug effects
Humans
In Vitro Techniques
Interstitial cells
Intestines - cytology
Intestines - drug effects
Intestines - embryology
Lectins - pharmacology
Liver cells
Pregnancy
Rats
Tumors
Viruses
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Summary:Concanavalin A markedly agglutinated isolated epithelial cells from the intestine of the human fetus but not from the intestine of the adult. Wheat germ agglutinin only moderately agglutinated cells from the intestine of an adult. These results extend the studies of concanavalin A agglutination of embryonic cells to human tissue, and they suggest that concanavalin A may be reacting with a common antigen on the fetal cell membrane.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.177.4048.525