Separation of Skin Reactive Intestinal Cancer Antigen from the Carcinoembryonic Antigen of Gold

Soluble fractions of human intestinal cancer and fetal intestinal cell membranes produced delayed hypersensitivity reactions in patients with intestinal cancer. These soluble fractions and perchloric acid extracts of intestinal cancer cells were fractionated by polacrylamide-gel electrophoresis. The...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1972-09, Vol.177 (4052), p.887-889
Main Authors: Hollinshead, Ariel C., McWright, C. Glen, Alford, T. Crandall, Glew, Donald H., Gold, Phil, Herberman, Ronald B.
Format: Article
Language:English
Subjects:
Antigens
Antigens - isolation & purification
Antigens, Neoplasm - isolation & purification
Cell membranes
Colonic Neoplasms - immunology
Coloring Agents
Diabetes
Electrophoresis
Fetus - immunology
Gels
Humans
Hypersensitivity, Delayed
Insulin
Intestinal neoplasms
Intestines - immunology
P branes
Reactivity
Rectal Neoplasms - immunology
Skin
Skin Tests
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Summary:Soluble fractions of human intestinal cancer and fetal intestinal cell membranes produced delayed hypersensitivity reactions in patients with intestinal cancer. These soluble fractions and perchloric acid extracts of intestinal cancer cells were fractionated by polacrylamide-gel electrophoresis. The Gold carcinoembryonic antigen was found in a region of the gels different from that of the skin reactive antigen.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.177.4052.887