Amino Acid Sequence of an Amyloid Fibril Protein of Unknown Origin

A group of human amyloid fibril proteins having chemical homology and antigenic similarities to immunoglobulin light polypeptide chains has been previously described. The amino acid sequence of a different type of human amyloid fibril protein is reported. This protein lacks valine, proline, threonin...

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Bibliographic Details
Published in:The Journal of biological chemistry 1972-09, Vol.247 (17), p.5653-5655
Main Authors: Ein, Daniel, Kimura, Shigeru, Terry, William D., Magnotta, Judith, Glenner, George G.
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Amino Acids - analysis
Amyloid - analysis
Chromatography, Thin Layer
Chymotrypsin
Dansyl Compounds
Humans
Hydrazines
Peptides - analysis
Peptides - isolation & purification
Trypsin
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Summary:A group of human amyloid fibril proteins having chemical homology and antigenic similarities to immunoglobulin light polypeptide chains has been previously described. The amino acid sequence of a different type of human amyloid fibril protein is reported. This protein lacks valine, proline, threonine, and half-cystine and its sequence is not homologous with any presently known immunoglobulin sequence. This sequence defines a new class of amyloid fibril proteins of as yet unknown origin.
ISSN:0021-9258
1083-351X
DOI:10.1016/S0021-9258(20)81154-5