Side-Chain Orientation in Fibrous Proteins

THE specific properties of proteins depend to a large extent upon the composition and arrangement of their side-chains, and a good deal of information has been accumulated recently on the amino-acid sequences of various proteins. Very little is known, however, of the stereochemistry of the side-chai...

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Bibliographic Details
Published in:Nature (London) 1955-08, Vol.176 (4477), p.358-359
Main Author: FRASER, R. D. B
Format: Article
Language:English
Subjects:
Humanities and Social Sciences
letter
multidisciplinary
Old Medline
Proteins - metabolism
Science
Science (multidisciplinary)
Scleroproteins
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Summary:THE specific properties of proteins depend to a large extent upon the composition and arrangement of their side-chains, and a good deal of information has been accumulated recently on the amino-acid sequences of various proteins. Very little is known, however, of the stereochemistry of the side-chain residues and the relations between side-chain configuration and orientation and the specific properties they confer on proteins. This is largely due to the lack of direct evidence, since X-ray diffraction diagrams obtained from fibrous proteins emphasize only the similarities between the configuration of the polypeptide backbone chain, while the very much richer diffraction patterns obtained from crystalline globular proteins have, as yet, only been interpreted in very general terms 1 .
ISSN:0028-0836
1476-4687
DOI:10.1038/176358a0