Reaction of Alloxan with Ascorbic Acid

IT has been reported from this laboratory 1 that, although acetoacetate alone causes an increase in the susceptibility to alloxan diabetes in rabbits, the product prepared by condensing acetoacetate with glucose (namely, 2-tetrahydroxy butyl, 5-methyl, 4-carboxy furan), in the form of its sodium sal...

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Bibliographic Details
Published in:Nature (London) 1955-10, Vol.176 (4486), p.787-788
Main Authors: NATH, M. C., BHATTATHIRY, E. P. M.
Format: Article
Language:English
Subjects:
Alloxan
Ascorbic Acid
Humanities and Social Sciences
letter
multidisciplinary
Old Medline
Science
Science (multidisciplinary)
Vitamins
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Summary:IT has been reported from this laboratory 1 that, although acetoacetate alone causes an increase in the susceptibility to alloxan diabetes in rabbits, the product prepared by condensing acetoacetate with glucose (namely, 2-tetrahydroxy butyl, 5-methyl, 4-carboxy furan), in the form of its sodium salt, when injected intraperitoneally or intravenously in rats and rabbits in the proportion of 1.5:1 with alloxan or even less, can prevent alloxan diabetes 2 . It has also recently been shown by Nath and Bhattathiry (unpublished results) that 1:2 dienol glucose, which is liberated from this condensation product on hydrolysis, reacts with alloxan.
ISSN:0028-0836
1476-4687
DOI:10.1038/176787a0