The association between obstructive sleep apnea syndrome and microvascular complications in well-controlled diabetic patients

Obstructive sleep apnea syndrome (OSAS) may promote hyperglycemia and insulin resistance. We studied the link between sleep apnea and microvascular diabetic complications in veterans with type 2 diabetes mellitus (DM-2). A retrospective electronic chart of all veterans referred for sleep studies ove...

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Bibliographic Details
Published in:Military medicine 2010-11, Vol.175 (11), p.913-916
Main Authors: Kosseifi, Semaan, Bailey, Beth, Price, Robert, Roy, Thomas M, Byrd, Jr, Ryland P, Peiris, Alan N
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Albuminuria - epidemiology
Body mass index
Cardiovascular disease
Coronary vessels
Diabetes
Diabetes Mellitus, Type 2 - epidemiology
Diabetic Angiopathies - epidemiology
Diabetic Angiopathies - prevention & control
Diabetic Retinopathy - epidemiology
Glucose
Hemoglobin
Humans
Hypertension
Insulin resistance
Medical records
Metabolism
Middle Aged
Patients
Retrospective Studies
Sensors
Sleep apnea
Sleep Apnea, Obstructive - epidemiology
Sleep Apnea, Obstructive - prevention & control
Statistical analysis
Stroke
United States - epidemiology
Vein & artery diseases
Veterans
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Summary:Obstructive sleep apnea syndrome (OSAS) may promote hyperglycemia and insulin resistance. We studied the link between sleep apnea and microvascular diabetic complications in veterans with type 2 diabetes mellitus (DM-2). A retrospective electronic chart of all veterans referred for sleep studies over a 1-year period was reviewed. Ninety-eight patients with a glycosylated hemoglobin < 6.5% were included in the study. The degree of glycemia (HbA1c) and presence of macro- and microvascular complications were compared with OSAS variables. Statistical analysis examined bivariate associations between OSAS variables and metabolic syndrome parameters. The apnea hypopnea index was significantly related to diabetic microvascular complications, particularly retinopathy. Oxygen desaturation was significantly and inversely related to microalbuminuria, microvascular complications, retinopathy, and HbA1c. Sleep apnea is associated with microvascular complications even in well-controlled DM-2 veterans. Screening for OSAS should be considered in patients with DM-2.
ISSN:0026-4075
1930-613X
DOI:10.7205/milmed-d-10-00131