Switching from high-efficacy lipid-lowering therapies to simvastatin and low-density lipoprotein cholesterol goal attainment in coronary heart disease/coronary heart disease-equivalent patients

Background The availability of generic simvastatin in 2006 has prompted substantial changes in formulary recommendations for lipid-management agents. Objective To assess the impact of switches from high-efficacy lipid-lowering therapy to simvastatin on low-density lipoprotein cholesterol (LDL-C) and...

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Bibliographic Details
Published in:Journal of clinical lipidology 2010-11, Vol.4 (6), p.491-500
Main Authors: Tunceli, Kaan, PhD, Sajjan, Shiva G., PhD, Ramey, Dena R., BA, Neff, David R., DO, Tershakovec, Andrew M., MD, MPH, Hu, X. Henry, MD, PhD, Tomassini, Joanne E., PhD, Foody, JoAnne M., MD
Format: Article
Language:English
Subjects:
Adult
Aged
Anticholesteremic Agents - therapeutic use
Atorvastatin Calcium
Azetidines - therapeutic use
Cardiovascular
Cardiovascular diseases
Cholesterol
Cholesterol, LDL - blood
Coronary Disease - drug therapy
Drug Therapy, Combination
Ezetimibe
Female
Fluorobenzenes - therapeutic use
Goal attainment
Heptanoic Acids - therapeutic use
Humans
Lipoproteins
Logistic Models
Male
Middle Aged
Odds Ratio
Pyrimidines - therapeutic use
Pyrroles - therapeutic use
Retrospective Studies
Rosuvastatin Calcium
Simvastatin - therapeutic use
Statin interventions
Sulfonamides - therapeutic use
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Summary:Background The availability of generic simvastatin in 2006 has prompted substantial changes in formulary recommendations for lipid-management agents. Objective To assess the impact of switches from high-efficacy lipid-lowering therapy to simvastatin on low-density lipoprotein cholesterol (LDL-C) and goal attainment in coronary heart disease (CHD) or CHD risk-equivalent patients in a managed care setting. Methods In this retrospective observational study, we estimated the least squares mean difference in the percent change from baseline LDL-C and the odds ratios for LDL-C goal attainment rates (
ISSN:1933-2874
1876-4789
DOI:10.1016/j.jacl.2010.10.004