Papillomatosis of nasal cavity and paranasal sinuses (inverted papilloma, squamous papilloma). A clinicopathologic study

• Published in: Cancer 1972-09, Vol.30 (3), p.668-690
• Main Authors: Snyder, Richard N., Perzin, Karl H.
• Format: Article
• Language: English
• Subjects: Age Factors; Aged; Female; Follow-Up Studies; Humans; Male; Maxillary Sinus; Middle Aged; Nasal Mucosa - pathology; Nasal Polyps - epidemiology; Neoplasm Recurrence, Local; Nose Neoplasms - epidemiology; Nose Neoplasms - pathology; Papilloma - epidemiology; Papilloma - pathology; Paranasal Sinus Neoplasms - epidemiology; Paranasal Sinus Neoplasms - pathology; Sex Factors; Time Factors
• ISSN: 0008-543X; 1097-0142
• DOI: 10.1002/1097-0142(197209)30:3<668::AID-CNCR2820300315>3.0.CO;2-B

Papillomatosis is an uncommon benign tumor involving the mucous membranes of the nasal cavity and paranasal sinuses. It was approximately 1/25 as frequent as the ordinary nasal polyp. Thirty‐nine patients with this condition have been studied, including clinical and pathologic findings. Recurrences were common (documented 49%, with another 25% probable). Features associated with higher rates of recurrence were epithelial atypia, epithelial mucus droplets, and involvement of sinuses. Carcinoma was associated with papillomatosis, but the extent of this relationship depended on the criteria used. Invasive carcinoma arising in documented recurrent papillomatosis was uncommon (one patient, 3%). In three other cases (8%), relatively small foci of carcinoma were found within extensive papillomatosis. In another four lesions (10%), the specimen resected for a large invasive carcinoma also showed incidental foci of papillomatosis. In these, however, it was difficult to prove that the carcinoma had actually arisen within the papillomatous epithelium. Recommendations for treatment are made.