Chronic Thyroiditis in the Rabbit Induced with Homologous Thyroid Microsomes

Rabbits immunized with freshly isolated homologous thyroid microsomes in complete Freund's adjuvant developed a severe chronic thyroiditis with the concomitant production of antimicrosomal antibodies. The antibody response was measured by indirect immunofluorescence and complement fixation, emp...

Full description

Saved in:
Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1972-10, Vol.178 (4058), p.316-318
Main Authors: Mangkornkanok, Marayart, Markowitz, A. S., Battifora, Hector A.
Format: Article
Language:English
Subjects:
Animals
Antibodies
Antibody Formation
Antigens
Antiserum
Autoantibodies - analysis
Chronic Disease
Complement Fixation Tests
Fluorescent Antibody Technique
Follicles
Freund's Adjuvant
Herpesviridae
Immunization
Leukocytes
Liver
Microsomes
Microsomes - immunology
Rabbits
Thyroid Gland - cytology
Thyroid Gland - immunology
Thyroiditis
Thyroiditis - etiology
Thyroiditis - immunology
Thyroiditis - pathology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Rabbits immunized with freshly isolated homologous thyroid microsomes in complete Freund's adjuvant developed a severe chronic thyroiditis with the concomitant production of antimicrosomal antibodies. The antibody response was measured by indirect immunofluorescence and complement fixation, employing isolated microsomes as the antigen. Microsomes but not thyroglobulin absorbed out the immunologic activity of the rabbit serum.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.178.4058.316