The effect of overweight and obesity on psoriasis patients in Chinese Han population: a hospital-based study

• Published in: Journal of the European Academy of Dermatology and Venereology 2011-01, Vol.25 (1), p.87-91
• Main Authors: Zhang, C, Zhu, KJ, Zheng, HF, Cui, Y, Zhou, FS, Chen, YL, Tang, XF, Li, M, Zhang, FY, Fan, X, Zuo, XB, Yang, S, Sun, LD, Zhang, XJ
• Format: Article
• Language: English
• Subjects: Body Mass Index; Case-Control Studies; China - epidemiology; Chinese Han population; clinical feature; Ethnic Groups; Hospitals; Humans; obesity; Obesity - complications; Obesity - epidemiology; overweight; Overweight - complications; Overweight - epidemiology; Prevalence; psoriasis; Psoriasis - complications; Psoriasis - epidemiology; Severity of Illness Index
• ISSN: 0926-9959; 1468-3083
• DOI: 10.1111/j.1468-3083.2010.03706.x

Background  Accumulating evidence indicates that psoriasis is associated with increased risk of overweight and obesity. However, few studies have investigated this relationship in Chinese Han population. Objective  The aim of this study was to explore the relationship between overweight/obesity and psoriasis and to evaluate the overweight/obesity effect on the clinical features of psoriasis in Chinese Han population. Methods  A hospital‐based study was conducted, which involved in 4452 patients and 1166 controls of Chinese Han through epidemiological investigation. Controls used in the study were individuals without psoriasis from health examination centre, and other skin disease patients from outpatient department. Results  Compared with the control group, a significantly greater prevalence of overweight and obesity was observed in psoriasis patients. The estimated ORs were 1.301 (95% CI, 1.105–1.531) and 1.680 (95% CI, 1.134–2.491) respectively. The disease severity of psoriasis measured by psoriasis area and severity index (PASI) was statistically correlated with body mass index (BMI) (r = 0.184, P