Efficacy and Tolerability of Fesoterodine in Older and Younger Subjects With Overactive Bladder

• Published in: Urology (Ridgewood, N.J.) N.J.), 2010-12, Vol.76 (6), p.1350-1357
• Main Authors: Kraus, Stephen R, Ruiz-Cerdá, José Luis, Martire, Diane, Wang, Joseph T, Wagg, Adrian S
• Format: Article
• Language: English
• Subjects: Adult; Age Factors; Aged; Aged, 80 and over; Benzhydryl Compounds - administration & dosage; Benzhydryl Compounds - adverse effects; Benzhydryl Compounds - therapeutic use; Biological and medical sciences; Constipation - chemically induced; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Medical sciences; Middle Aged; Muscarinic Antagonists - administration & dosage; Muscarinic Antagonists - adverse effects; Muscarinic Antagonists - therapeutic use; Nephrology. Urinary tract diseases; Patient Dropouts; Randomized Controlled Trials as Topic - statistics & numerical data; Surveys and Questionnaires; Urinary Bladder, Overactive - drug therapy; Urinary Incontinence, Urge - drug therapy; Urinary system involvement in other diseases. Miscellaneous; Urinary tract. Prostate gland; Urology; Xerostomia - chemically induced; Young Adult
• ISSN: 0090-4295; 1527-9995
• DOI: 10.1016/j.urology.2010.03.097

Objectives To assess the effect of age on fesoterodine efficacy and tolerability in subjects with an overactive bladder. Methods The data from 2 randomized, 12-week studies of 1681 subjects treated with fesoterodine 4 or 8 mg or placebo were pooled and stratified by age. The subjects completed 3-day bladder diaries at baseline and weeks 2 and 12, the King's Health Questionnaire at baseline and week 12, and the Treatment Benefit Scale at week 12. Results Of the subjects aged