Major Depression Drives Severity of American Urological Association Symptom Index

Objectives To evaluate the unclear relationship between depression and benign prostatic hyperplasia (BPH) by assessing depression's effect on the American Urological Association Symptom Index (AUA-SI) scores. Depression is a common illness associated with chronic inflammatory disease states. Da...

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Bibliographic Details
Published in:Urology (Ridgewood, N.J.) N.J.), 2010-12, Vol.76 (6), p.1317-1320
Main Authors: Johnson, Timothy V, Abbasi, Ammara, Ehrlich, Samantha S, Kleris, Renee S, Chirumamilla, Siri L, Schoenberg, Evan D, Owen-Smith, Ashli, Raison, Charles L, Master, Viraj A
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Aged
Biological and medical sciences
Causality
Chronic Disease
Cohort Studies
Comorbidity
Cross-Sectional Studies
Depression
Depressive Disorder, Major - epidemiology
Depressive Disorder, Major - psychology
Humans
Inflammation - epidemiology
Inflammation - psychology
Logistic Models
Male
Medical sciences
Middle Aged
Mood disorders
Nephrology. Urinary tract diseases
Odds Ratio
Prostatic Hyperplasia - epidemiology
Prostatic Hyperplasia - psychology
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Severity of Illness Index
Socioeconomic Factors
Urology
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Summary:Objectives To evaluate the unclear relationship between depression and benign prostatic hyperplasia (BPH) by assessing depression's effect on the American Urological Association Symptom Index (AUA-SI) scores. Depression is a common illness associated with chronic inflammatory disease states. Data have suggested a significant role of inflammation in the progression of BPH. Methods The present prospective study involved 547 male patients who completed the Geriatric Depression Scale and the AUA-SI. We evaluated whether the mean AUA-SI score and the severity categories differed by the state of depression. We then conducted binary logistic regression analysis with forward stepwise regression to assess the relationship between depression and the severity symptoms as determined by the AUA-SI score. Results Of the cohort, 22% screened positive for depressive symptoms. The depressed patients (Geriatric Depression Scale score >5) reported significantly more severe symptoms (mean AUA-SI score 16.61 ± 9.89) compared with the nondepressed patients (Geriatric Depression Scale score of ≤5 and mean AUA-SI score 10.65 ± 7.29; F = 40.19, P
ISSN:0090-4295
1527-9995
DOI:10.1016/j.urology.2010.01.069