A Pressor Substance in the Cerebrospinal Fluid of Normotensive and Hypertensive Patients

A pressor polypeptide was isolated from the cerebrospinal fluid of normotensive and hypertensive patients. Pharmacologically it behaves like angiotensin I. A very significant correlation (r = 0.83, P < 0.001) was found between the concentration of this polypeptide and the blood pressure of essent...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1972-11, Vol.69 (11), p.3341-3344
Main Authors: Finkielman, Samuel, Fischer-Ferraro, Catalina, Diaz, Alberto, Goldstein, Daniel J., Nahmod, Victor E.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Angiotensin II - blood
Angiotensin II - pharmacology
Animals
Bioassay
Biological Assay
Biological Sciences: Medical Sciences
Blood
Blood Pressure
Central nervous system diseases
Cerebrospinal fluid
Chromatography, Gel
Female
Humans
Hypertension
Hypertension - blood
Hypertension - cerebrospinal fluid
Hypertension, Malignant - cerebrospinal fluid
Ileum
Ileum - drug effects
Male
Middle Aged
Nephrectomy
Nervous system diseases
Radioimmunoassay
Rats
Uterus
Uterus - drug effects
Vasoconstrictor Agents - cerebrospinal fluid
Vasoconstrictor Agents - isolation & purification
Vasoconstrictor Agents - pharmacology
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Description
Summary:A pressor polypeptide was isolated from the cerebrospinal fluid of normotensive and hypertensive patients. Pharmacologically it behaves like angiotensin I. A very significant correlation (r = 0.83, P < 0.001) was found between the concentration of this polypeptide and the blood pressure of essential hypertensive patients.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.69.11.3341