Hemoglobin Lepore Trait: Globin Synthesis in Bone Marrow and Peripheral Blood

There was decreased synthesis of the β-globin chain in the peripheral blood, and equal synthesis of α- and non-α-chains in the bone marrow of three patients with hemoglobin Lepore trait, similar to the findings in patients with heterozygous β-thalassemia. There is a relative instability of the synth...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1972-11, Vol.178 (4061), p.623-625
Main Authors: Gill, Frances, Atwater, Jean, Schwartz, Elias
Format: Article
Language:English
Subjects:
Animal cells
Bacteria
Bacterial RNA
Blood
Bone marrow
Bone Marrow - metabolism
Carbon Isotopes
Chromatography
Fleas
Globins - analysis
Globins - biosynthesis
Hemoglobinopathies - blood
Hemoglobinopathies - metabolism
Hemoglobins
Humans
Leucine - metabolism
Neurons
Radioactive decay
RNA
Thalassemia - metabolism
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Description
Summary:There was decreased synthesis of the β-globin chain in the peripheral blood, and equal synthesis of α- and non-α-chains in the bone marrow of three patients with hemoglobin Lepore trait, similar to the findings in patients with heterozygous β-thalassemia. There is a relative instability of the synthetic mechanism for normal β-chain in these patients.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.178.4061.623