Safety and efficacy of long-term statin treatment for cardiovascular events in patients with coronary heart disease and abnormal liver tests in the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) Study: a post-hoc analysis

Summary Background Long-term statin treatment reduces the frequency of cardiovascular events, but safety and efficacy in patients with abnormal liver tests is unclear. We assessed whether statin therapy is safe and effective for these patients through post-hoc analysis of the Greek Atorvastatin and...

Full description

Saved in:
Bibliographic Details
Published in:The Lancet (British edition) 2010-12, Vol.376 (9756), p.1916-1922
Main Authors: Athyros, Vasilios G, MD, Tziomalos, Konstantinos, MD, Gossios, Thomas D, MD, Griva, Theodora, MD, Anagnostis, Panagiotis, MD, Kargiotis, Konstantinos, MD, Pagourelias, Efstathios D, MD, Theocharidou, Eleni, MD, Karagiannis, Asterios, Prof, Mikhailidis, Dimitri P, Dr
Format: Article
Language:English
Subjects:
Aged
Atherosclerosis
Biological and medical sciences
Cardiology. Vascular system
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - drug therapy
Coronary Disease - complications
Coronary Disease - drug therapy
Coronary heart disease
Data collection
Diabetes
Fatty Liver - blood
Fatty Liver - complications
Fatty Liver - drug therapy
Female
General aspects
Greece
Heart
Heart failure
Hospitals
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
Insulin resistance
Internal Medicine
Liver
Liver Function Tests
Male
Medical sciences
Middle Aged
Mortality
Non-alcoholic Fatty Liver Disease
Prospective Studies
Recurrence
Regression analysis
Risk Reduction Behavior
Statins
Time Factors
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary Background Long-term statin treatment reduces the frequency of cardiovascular events, but safety and efficacy in patients with abnormal liver tests is unclear. We assessed whether statin therapy is safe and effective for these patients through post-hoc analysis of the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) study population. Methods GREACE was a prospective, intention-to-treat study that randomly assigned by a computer-generated randomisation list 1600 patients with coronary heart disease (aged 2·6 mmol/L and triglycerides
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(10)61272-X