Clinical proteomics: A need to define the field and to begin to set adequate standards

The aim of this manuscript is to initiate a constructive discussion about the definition of clinical proteomics, study requirements, pitfalls and (potential) use. Furthermore, we hope to stimulate proposals for the optimal use of future opportunities and seek unification of the approaches in clinica...

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Bibliographic Details
Published in:Proteomics. Clinical applications 2007-02, Vol.1 (2), p.148-156
Main Authors: Mischak, Harald, Apweiler, Rolf, Banks, Rosamonde E., Conaway, Mark, Coon, Joshua, Dominiczak, Anna, Ehrich, Jochen H. H., Fliser, Danilo, Girolami, Mark, Hermjakob, Henning, Hochstrasser, Denis, Jankowski, Joachim, Julian, Bruce A., Kolch, Walter, Massy, Ziad A., Neusuess, Christian, Novak, Jan, Peter, Karlheinz, Rossing, Kasper, Schanstra, Joost, Semmes, O. John, Theodorescu, Dan, Thongboonkerd, Visith, Weissinger, Eva M., Van Eyk, Jennifer E., Yamamoto, Tadashi
Format: Article
Language:English
Subjects:
Biomarker
Clinical diagnostics
Protein marker discovery
Protein profiling
Proteome analysis
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Summary:The aim of this manuscript is to initiate a constructive discussion about the definition of clinical proteomics, study requirements, pitfalls and (potential) use. Furthermore, we hope to stimulate proposals for the optimal use of future opportunities and seek unification of the approaches in clinical proteomic studies. We have outlined our collective views about the basic principles that should be considered in clinical proteomic studies, including sample selection, choice of technology and appropriate quality control, and the need for collaborative interdisciplinary efforts involving clinicians and scientists. Furthermore, we propose guidelines for the critical aspects that should be included in published reports. Our hope is that, as a result of stimulating discussion, a consensus will be reached amongst the scientific community leading to guidelines for the studies, similar to those already published for mass spectrometric sequencing data. We contend that clinical proteomics is not just a collection of studies dealing with analysis of clinical samples. Rather, the essence of clinical proteomics should be to address clinically relevant questions and to improve the state‐of‐the‐art, both in diagnosis and in therapy of diseases.
ISSN:1862-8346
1862-8354
DOI:10.1002/prca.200600771