Antibody microarray analysis of serum glycans in esophageal squamous cell carcinoma cases and controls

The objective of this study was to characterize specific serum glycan profile in esophageal squamous cell carcinoma (ESCC) cases and matched controls. A recently developed lectin‐based antibody array was applied to detect various cancer‐associated glycotopes in sera from 23 cases and 23 controls. Gl...

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Bibliographic Details
Published in:Proteomics. Clinical applications 2009-08, Vol.3 (8), p.923-931
Main Authors: Shao, Changxia, Chen, Songming, Chen, Lixia, Cobos, Everardo, Wang, Jia‐Sheng, Haab, Brian B., Gao, Weimin
Format: Article
Language:English
Subjects:
Antibody microarray
Biological and medical sciences
Diverse techniques
Esophageal cancer
Esophagus
Fundamental and applied biological sciences. Psychology
Gastroenterology. Liver. Pancreas. Abdomen
Glycan
Glycoprotein
Lectin
Medical sciences
Molecular and cellular biology
Tumors
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Summary:The objective of this study was to characterize specific serum glycan profile in esophageal squamous cell carcinoma (ESCC) cases and matched controls. A recently developed lectin‐based antibody array was applied to detect various cancer‐associated glycotopes in sera from 23 cases and 23 controls. Glycan levels were highly expressed in sera of ESCC patients as compared with controls. These included fucosylation level on interleukin (IL) 8; mannose level on haptoglobin; N‐acetylglucosamine levels on IL6, mucin (MUC)1, and von Willebrand factor (vWf); sialyl Lewis a (sLea) levels on blood group Lewis X, IL6, IL10, MUC1, and serum amyloid A (SAA); sialyl Tn antigen (sTn) levels on cathepsin D, gelsolin, IL10, and vWf; T antigen levels on IL8, IL10, blood group Lewis X, vitronectin, and vWf (p
ISSN:1862-8346
1862-8354
DOI:10.1002/prca.200800245