Liver proteins as sensor of human malignancies and inflammation

In this review we would like to highlight the importance of acute‐phase proteins as sensor of diseases. Both acute‐phase protein levels and glycosylation have been reported to be altered in inflammation and other diseases including cancer. Factors that promote acute‐phase protein synthesis and enhan...

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Bibliographic Details
Published in:Proteomics. Clinical applications 2010-04, Vol.4 (4), p.426-431
Main Authors: Peracaula, Rosa, Sarrats, Ariadna, Rudd, Pauline M.
Format: Article
Language:English
Subjects:
Acute-phase proteins
Acute-Phase Proteins - analysis
Biomarkers - blood
Cancer
Glycosylation
Humans
Inflammation
Liver - pathology
Liver Neoplasms - diagnosis
Liver Neoplasms - pathology
Serum
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Summary:In this review we would like to highlight the importance of acute‐phase proteins as sensor of diseases. Both acute‐phase protein levels and glycosylation have been reported to be altered in inflammation and other diseases including cancer. Factors that promote acute‐phase protein synthesis and enhance the expression of specific glycosyltransferases, such as sialyltransferases and fucosyltransferases, may be up‐regulated in some tumours and would explain the changes in acute‐phase protein levels and the specific N‐glycosylation modifications of some acute‐phase proteins in cancer. However, further studies are required to define the potential clinical application of these acute‐phase protein cancer‐specific modifications as possible cancer diagnostic or monitoring tools.
ISSN:1862-8346
1862-8354
DOI:10.1002/prca.200900170