FACTORS AFFECTING PLASMA LEVELS OF LIGNOCAINE AND PRILOCAINE

Plasma levels of local anaesthetics following their injection are affected by many factors. Serial plasma levels following injection of lignocaine and prilocaine at various rates in over 500 patients have been measured and this has allowed some of these factors to be assessed and quantified. The vas...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1972-10, Vol.44 (10), p.1040-1049
Main Authors: SCOTT, D.B., JEBSON, P.J.R., BRAID, D.P., ÔRTENGREN, B., FRISCH, P.
Format: Article
Language:English
Subjects:
Abdomen - blood supply
Adult
Age Factors
Aged
Anesthesia, Epidural
Anesthesia, Local
Body Weight
Capillaries
Epinephrine - administration & dosage
Female
Humans
Injections, Intramuscular
Injections, Intravenous
Injections, Subcutaneous
Intercostal Muscles - blood supply
Lidocaine - administration & dosage
Lidocaine - blood
Lumbosacral Region - blood supply
Middle Aged
Prilocaine - administration & dosage
Prilocaine - blood
Time Factors
Vagina - blood supply
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Summary:Plasma levels of local anaesthetics following their injection are affected by many factors. Serial plasma levels following injection of lignocaine and prilocaine at various rates in over 500 patients have been measured and this has allowed some of these factors to be assessed and quantified. The vascularity of the site of injection causes major differences in the maximum plasma level. Prilocaine consistently gives lower levels than lignocaine. Adrenaline causes a reduction in the plasma levels of both drugs and the optimal concentration is 1:200,000. Speed of injection is important when giving the drugs intravenously but not epidurally. The concentration of the injected solution does not affect the plasma levels. The weight and age of the patients (all adult females) were unrelated to the mayi'mnm plasma levels.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/44.10.1040