Renin in Rats with Spontaneous Hypertension

An age-dependent study of plasma renin activity (PRA), kidney renin activity (KRA), and plasma renin substrate was carried out in rats with spontaneous hypertension during the prehypertensive, the early hypertensive, and the established hypertensive phases of their disease. PRA and KRA were both sig...

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Bibliographic Details
Published in:Circulation research 1972-12, Vol.31 (6), p.876-880
Main Authors: SEN, SUBHA, SMEBY, ROBERT R, BUMPUS, F Merlin
Format: Article
Language:English
Subjects:
Age Factors
Angiotensin II - analysis
Angiotensin II - blood
Animals
Biological Assay
Body Weight
Hypertension - blood
Hypertension - genetics
Kidney - analysis
Rats
Renin - analysis
Renin - blood
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Summary:An age-dependent study of plasma renin activity (PRA), kidney renin activity (KRA), and plasma renin substrate was carried out in rats with spontaneous hypertension during the prehypertensive, the early hypertensive, and the established hypertensive phases of their disease. PRA and KRA were both significantly elevated before and during the initial phase of hypertension and normal or subnormal during the established phase. In normal controls, neither KRA nor PRA was significantly different during the entire growth period. Plasma renin substrate was elevated throughout the growth period in rats with hypertension. This relationship between renin and blood pressure suggests that renin may play a primary role, possibly along with other factors, in the initiation of hypertension in rats with spontaneous hypertension.
ISSN:0009-7330
1524-4571
DOI:10.1161/01.RES.31.6.876