Distribution of 5-Fluorouracil-2-14 C and Its Metabolites in a Murine Glioma

The uptake and distribution of 5-fluorouracil-2-14C (FU) and its metabolites were determined in normal brain and an intracerebral glioma of C57BL/6 mice during maintenance of a steady-state concentration of FU in plasma. After 1 hour, FU reached a concentration in tumor approximately 11 times that i...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1972-12, Vol.49 (6), p.1577-1584
Main Authors: Levin, Victor A., Chadwick, Marjory
Format: Article
Language:English
Subjects:
Animals
Brain - metabolism
Brain Neoplasms - metabolism
Carbon Isotopes
Chromatography, Ion Exchange
Chromatography, Thin Layer
Ependymoma - metabolism
Floxuridine - metabolism
Fluorouracil - administration & dosage
Fluorouracil - blood
Fluorouracil - metabolism
Glioma - metabolism
Half-Life
Injections, Intraperitoneal
Kinetics
Mice
Mice, Inbred C57BL
Neoplasms, Experimental - metabolism
Propionates - metabolism
Time Factors
Uracil Nucleotides - metabolism
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Summary:The uptake and distribution of 5-fluorouracil-2-14C (FU) and its metabolites were determined in normal brain and an intracerebral glioma of C57BL/6 mice during maintenance of a steady-state concentration of FU in plasma. After 1 hour, FU reached a concentration in tumor approximately 11 times that in normal brain. 5-Fluoro-2′-deoxyuridine-5′-monophesphate (FdUMP), believed to be the chemotherapeutically active metabolite, was identified in intracerebral tumor.
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/49.6.1577