Enhancement of Endotoxin-Induced Virus-Inhibiting Factor or Interferon Production by Pretreatment of the Rabbit with Newcastle Disease Virus

ABSTRACT Rabbits pretreated by intravenous injection with Newcastle disease virus (NDV) produced high‐titered virus‐inhibiting factor (IF) or interferon in the serum upon intravenous injection of Escherichia coli endotoxin 24 hr later as compared with the IF production induced by endotoxin in rabbit...

Full description

Saved in:
Bibliographic Details
Published in:Japanese Journal of Microbiology 1972-05, Vol.16 (5), p.397-402
Main Authors: Nagano, Yasuiti, Maehara, Nobutoshi
Format: Article
Language:English
Subjects:
Animals
Endotoxins - pharmacology
Escherichia coli
Interferon Inducers
Interferons - analysis
Interferons - biosynthesis
Kidney - analysis
Liver - analysis
Lung - analysis
Lymph Nodes - analysis
Newcastle disease virus
Omentum - analysis
Rabbits
Spleen - analysis
Thymus Gland - analysis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:ABSTRACT Rabbits pretreated by intravenous injection with Newcastle disease virus (NDV) produced high‐titered virus‐inhibiting factor (IF) or interferon in the serum upon intravenous injection of Escherichia coli endotoxin 24 hr later as compared with the IF production induced by endotoxin in rabbits without the NDV pretreatment. IF assays of different organs revealed that the NDV pretreatment rendered the spleen rather hyporeactive but other organs such as the liver, lungs and kidneys hyperreactive to the subsequent IF induction by endotoxin. The enhanced IF titer observed in the serum seems to be the summation of IF released from various organs rendered hyporeactive or hyperreactive by the NDV pretreatment. It is postulated that the late‐appearing, heat‐ and acid‐stable IF and the early‐appearing, heat‐ and acid‐labile IF are produced by different processes in different types of cells. The production of early IF consists of two steps, formation of “preinterferon” and conversion of preinterferon to early IF. Preinterferon formation is induced by virus but not by endotoxin, while the conversion of preinterferon to early IF is effected by both endotoxin and virus. The formation of late IF is induced only by virus, taking a one‐step process. This hypothesis seems to explain the findings in the present study.
ISSN:0021-5139
1348-0421
DOI:10.1111/j.1348-0421.1972.tb00674.x