Changes in Neurons and Gliocytes in the Mesoaccumbocingulate System on Perinatal Exposure to Morphine in Rats

Studies of changes in the numbers and some morphometric parameters of neurons and gliocytes in the mesoaccumbocingulate (MAC) dopaminergic system in rats were performed using pre- and postnatal exposure of this system to opiates, i.e., 0.1 mg as 1% morphine hydrochloride solution into the amnion of...

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Bibliographic Details
Published in:Neuroscience and behavioral physiology 2010-10, Vol.40 (8), p.848-851
Main Authors: Droblenkov, A. V., Karelina, N. R., Shabanov, P. D.
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Behavioral Sciences
Biomedical and Life Sciences
Biomedicine
Dopamine
Female
Gyrus Cinguli - drug effects
Gyrus Cinguli - pathology
Morphine
Morphine - pharmacology
Narcotics
Neurobiology
Neuroglia - drug effects
Neuroglia - pathology
Neurons
Neurons - drug effects
Neurons - pathology
Neurosciences
Nucleus Accumbens - drug effects
Nucleus Accumbens - pathology
Pregnancy
Prenatal Exposure Delayed Effects - pathology
Rats
Rats, Wistar
Receptors, Dopamine - metabolism
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Summary:Studies of changes in the numbers and some morphometric parameters of neurons and gliocytes in the mesoaccumbocingulate (MAC) dopaminergic system in rats were performed using pre- and postnatal exposure of this system to opiates, i.e., 0.1 mg as 1% morphine hydrochloride solution into the amnion of fetuses of female Wistar rats ( n = 4) on post-fertilization day 17 or i.p. to rat pups on postnatal day 4 ( n = 4). Perinatal exposure to morphine induced chromophilic degeneration, swelling, and the death of some neurons, along with decreases in the volumes of other (less damaged) neurons in the MAC system of rats. Neuron damage, more marked after prenatal administration, was accompanied by an increase in the number of microgliocytes and their phagocytic activity. Morphine did not alter the number of satellite macrogliocytes or the mean distance from these cells to the bodies of less damaged neurons.
ISSN:0097-0549
1573-899X
DOI:10.1007/s11055-010-9334-0