Prefrontal cortex plasticity mechanisms in drug seeking and relapse

Development of pharmacotherapy to reduce relapse rates is one of the biggest challenges in drug addiction research. The enduring nature of relapse suggests that it is maintained by long-lasting molecular and cellular adaptations in the neuronal circuitry that mediates learning and processing of moti...

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Bibliographic Details
Published in:Neuroscience and biobehavioral reviews 2010-11, Vol.35 (2), p.276-284
Main Authors: Van den Oever, Michel C., Spijker, Sabine, Smit, August B., De Vries, Taco J.
Format: Article
Language:English
Subjects:
Adaptations
Addiction
Animals
Cocaine
Drug-Seeking Behavior - physiology
Heroin
Humans
Models, Neurological
Neural Pathways - drug effects
Neural Pathways - physiopathology
Neuroadaptations
Neuronal Plasticity - drug effects
Neuronal Plasticity - physiology
Prefrontal cortex
Prefrontal Cortex - drug effects
Prefrontal Cortex - physiopathology
Recurrence
Reinstatement
Relapse
Street Drugs - pharmacology
Substance-Related Disorders - physiopathology
Substance-Related Disorders - prevention & control
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Summary:Development of pharmacotherapy to reduce relapse rates is one of the biggest challenges in drug addiction research. The enduring nature of relapse suggests that it is maintained by long-lasting molecular and cellular adaptations in the neuronal circuitry that mediates learning and processing of motivationally relevant stimuli. Studies employing the reinstatement model of drug relapse in rodents point to an important role of the medial prefrontal cortex (mPFC), with distinct contributions of the dorsal and ventral regions of the mPFC to drug-, stress- and cue-induced drug seeking. Whereas drug-induced neuroadaptations in the dorsal mPFC function to enhance excitatory output and drive expression of drug seeking, recent evidence suggests that plasticity in the ventral mPFC leads to reduced glutamatergic transmission in this region, thereby impairing response inhibition upon exposure to drug-conditioned stimuli. Treatments aimed at restoring drug-induced neuroadaptations in the mPFC may help to reduce cue-reactivity and relapse susceptibility.
ISSN:0149-7634
1873-7528
DOI:10.1016/j.neubiorev.2009.11.016